Catholic men continue to answer God's call to educational service as De La Salle Christian Brothers, particularly to the young isolated by poverty. Brothers meet the challenges of their mission through the support of daily prayer and life together in community. In over 80 countries, De La Salle Christian Brothers respond to the Founder's call "to touch hearts". In 2000, Brothers in the San Francisco District number 137, nearly 50% of whom serve in educational works. Twelve serve at the District, Regional, or Institute level, and five work in overseas ministries. Thirty-six are retired.

Mont La Salle (right), located on 504 acres in Napa, California, was purchased by the Brothers in 1930, and is the current site of De La Salle Institute's administrative offices, the District's Provincialate, Novitiate, and Holy Family Communities, Mont La Salle Retreat and Conference Center, and the Brothers' cemetery. Over the years, the property has also been home to the Christian Brothers Winery, Junior Novitiate, and Saint Mary's Residence School for Boys, which closed in 1986. The winery operations were sold in 1989, and the winery buildings and acreage, including vineyards, are now leased to the Hess Collection Wine Company.